The objective of the present study was to investigate whether the technique of Solid Dispersion would be helpful for enhancing the dissolution of Meloxicam. Solid dispersions of Meloxicam were prepared by solvent evaporation method using carriers such as Sodium Starch Glycolate, Croscarmellose sodium. Solid dispersions were characterized by differential scanning calorimetry and evaluated for dissolution profiles of meloxicam. A marked increase in dissolution rate was observed with all solid dispersion. Among the carriers studied sodium starch glycolate gave the highest improvement in dissolution rate. Selected dispersions were used to prepare tablets, which were evaluated for the dissolution profiles of meloxicam and also subjected to stability studies. In vivo studies were carried out by treating rats orally with pure meloxicam and dispersion of meloxicam to investigate reduction in ulcerogenecity and the solvent evaporated dispersion was found to reduce the ulcerogenecity of the drug.
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